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. 2019 Sep 5;4(17):e129359. doi: 10.1172/jci.insight.129359

Figure 7. Syndecan-1 dependence of EVs in modulating lung fibrosis.

Figure 7

WT mice were injured with bleomycin (0.75 unit/kg) and then intratracheally instilled with fibrotic EVs isolated from bleomycin-injured WT and Sdc1–/– mice. Representative images of (A) H&E and (B) Picrosirius red staining and (C) hydroxyproline content (n = 12–15 per group) of lungs recovered from WT versus Sdc1–/– fibrotic EV–treated mice; scale bar: 200 μm. Original magnification ×20.*P < 0.05; **P < 0.005 by 1-way ANOVA analysis.