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. 2019 Sep 5;4(17):e122688. doi: 10.1172/jci.insight.122688

Figure 6. Expression profiling of AR-responsive genes in mouse Pten-deficient prostate tumors treated with ISIS581088.

Figure 6

Sixteen-week-old mice with castration-naive (CNPC) or castration-resistant prostate tumors (CRPC, 6 weeks after surgical castration) were treated with saline (n = 5), control ASO (n = 6), or ISIS581088 (n = 6) for 4 weeks as described in Figure 3A and Figure 5A. Prostate tumors were collected for multiplex gene expression analysis of AR responsive genes using the Fluidigm analysis platform. (A) Heatmap and unsupervised hierarchical clustering (average linkage, Euclidean distance metric) of 86 AR-responsive genes after Ar silencing with ISIS581088 (see Supplemental Table 2). (B) Top biological processes enriched after Ar silencing in castration-naive prostate tumors.