Figure 1. .

Principles of cortical wiring integrate regularities of cortical architecture, connectivity, and function through mechanistic explanations. Connections create functions of brain areas, and functional interactions among areas, from the structural substrate of the brain, and specifically the cortical sheet. In particular, areas are linked through connections which have a laminar composition that is appropriate for the laminar microenvironment within the respective areas as well as the type of information exchange between these areas. Thus, local cortical architecture, the connection features of a cortical area, and an area’s functional role within the cortical network are tightly intertwined. Adapted from Beul and Hilgetag (2019).