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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Clin Pharmacol Ther. 2019 Jul 4;106(5):1067–1075. doi: 10.1002/cpt.1507

Table 4.

Operational definition of serious bleeding.

Outcome component Discharge diagnosis descriptor Discharge diagnosis ICD-9-CM code(s) Discharge diagnosis position and claim type Positive predictive value
Gastrointestinal bleeding esophageal ulcer, with hemorrhage 530.21 Any-position discharge diagnosis on an inpatient hospitalization claim ~81%
gastric ulcer, with hemorrhage 531.0X, 531.2X, 531.4X, 531.6X
duodenal ulcer, with hemorrhage 532.0X, 532.2X, 532.4X, 532.6X
peptic ulcer, with hemorrhage 533.0X, 533.2X, 533.4X, 533.6X
gastrojejunal ulcer, with hemorrhage 534.0X, 534.2X, 534.4X, 534.6X
gastritis and duodenitis, with hemorrhage 535.01, 535.11, 535.21, 535.31, 535.41, 535.51, 535.61, 535.71
other specified disorder of stomach and duodenum, with hemorrhage 537.83, 537.84
diverticula of intestine, with hemorrhage 562.02, 562.03, 562.12, 562.13
other disorders of intestine, with hemorrhage 569.85, 569.86
gastrointestinal hemorrhage 578.X
Intracranial hemorrhage subarachnoid hemorrhage 430 Any-position discharge diagnosis on an emergency department or inpatient hospitalization claim ~77–94%
intracerebral hemorrhage 431

ICD-9-CM = international classification of diseases 9th revision clinical modification