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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2019 Jul 2;144:106353. doi: 10.1016/j.prostaglandins.2019.106353

Figure 4. CB6F1 mice become hyperinsulinemic and insulin resistant when fed a HFD.

Figure 4.

The effects of dietary fat on insulin resistance was assessed in 20 week old CB6F1 mice. A. Dietary fat had no effect on blood glucose after a 6-hour fast (P = 0.3653). B. Increasing dietary fat increased fasting plasma insulin (P = 0.0001). C. The homeostatic model assessment of insulin resistance (HOMA-IR), a function of fasting blood glucose and plasma insulin, revealed that increasing dietary fat increased insulin resistance (P = 0.0008). For all figures N = 8 control, 8 HFD, 9 VHFD. Values are expressed as mean ± SEM.