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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2019 Jul 2;144:106353. doi: 10.1016/j.prostaglandins.2019.106353

Table 1. Fatty acid composition of hepatic triglycerides.

Fatty acid composition of hepatic triglycerides from male EP3+/+ and EP3−/− mice, fed either HFD or control diet. N = 4 control + vehicle, 3 control + DG-041, 4 HFD + vehicle, 4 HFD + DG-041, 4 VHFD + vehicle, 5 VHFD + DG-041.

Parameter control + vehicle control + DG-041 HFD + vehicle HFD + DG-041 VHFD + vehicle VHFD + DG-041 ANOVA p-value
mean SEM mean SEM mean SEM mean SEM mean SEM mean SEM DG-041 Diet Interaction
g/100 g fatty acids
14:0 0.90 0.06 0.85 0.06 0.09 0.08 0.00 0.00 0.13 0.08 0.22 0.06 0.772 < 0.001 0.335
16:0 25.14*** 0.31 28.81*** 0.77 24.35 0.64 23.68 0.29 26.10 0.28 26.15 0.42 0.015 < 0.001 0.001
16:1 5.83 0.48 6.26 0.22 1.65 0.26 1.50 0.09 1.12 0.01 1.24 0.10 0.506 < 0.001 0.523
17:0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 NA NA NA
18:0 1.99 0.06 1.72 0.04 2.67 0.38 2.30 0.10 2.23 0.03 2.15 0.09 0.100 0.008 0.668
18:1ω9 43.14 1.05 44.96 1.58 35.74 1.62 36.74 0.18 32.68 0.35 35.23 0.53 0.038 < 0.001 0.717
18:1ω7 6.90 0.42 7.01 0.08 1.83 0.22 1.79 0.09 1.34 0.04 1.41 0.09 0.781 < 0.001 0.929
18:2 12.50** 0.72 7.88** 1.07 27.40 1.05 27.87 0.20 27.96* 0.24 25.37* 0.66 0.001 < 0.001 0.009
18:3ω6 0.00 0.00 0.00 0.00 0.54 0.18 0.33 0.19 0.73 0.02 0.67 0.03 0.339 < 0.001 0.633
18:3ω3 0.54 0.03 0.29 0.04 0.60 0.20 0.79 0.09 1.10 0.12 0.93 0.05 0.397 < 0.001 0.123
20:3ω6 0.50 0.02 0.43 0.09 0.64 0.22 0.61 0.21 0.85 0.03 1.05 0.03 0.526 0.004 0.765
20:4 1.39* 0.08 0.92* 0.18 1.87 0.11 1.89 0.12 1.99 0.05 1.98 0.09 0.094 < 0.001 0.060
20:5 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.06* 0.06 0.20* 0.05 0.154 0.002 0.123
22:4ω6 0.21 0.12 0.26 0.06 0.24 0.14 0.22 0.12 0.51 0.02 0.59 0.04 0.698 0.004 0.858
22:5ω6 0.19 0.11 0.10 0.10 0.16 0.09 0.00 0.00 0.15 0.09 0.16 0.07 0.287 0.592 0.573
22:5ω3 0.06 0.06 0.08 0.08 0.25 0.14 0.24 0.14 0.53 0.01 0.51 0.02 0.974 < 0.001 0.976
22:6 0.71 0.11 0.44 0.14 1.99 0.20 2.05 0.07 2.54 0.05 2.14 0.12 0.065 < 0.001 0.180
Ratio
16:0/16:1 4 40*** 0.36 4 60*** 0.09 15.71 2.08 15.95 1.03 23.33 0.34 21.49 1.66 0.673 < 0.001 0.656
18:0/18:1 0.04 0.00 0.03 0.00 0.07 0.01 0.06 0.00 0.07 0.00 0.06 0.00 0.007 < 0.001 0.778
Saturated / Unsaturated† 0.39 0.00 0.46 0.02 0.37 0.01 0.35 0.01 0.40 0.00 0.40 0.01 0.034 < 0.001 < 0.001
†

(14:0+16:0+17:0+18:0) / (16:1+18:1ω9+18:1ω7+18:2+18:3ω6+18:3ω3+20:3ω6+20:4+20:5+22:4ω6+22:5ω6+22:5ω3+22:6)

*

Bonferroni post-hoc comparison P<0.05

**

Bonferroni post-hoc comparison P<0.01

***

Bonferroni post-hoc comparison P<0.001