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. Author manuscript; available in PMC: 2020 Oct 3.
Published in final edited form as: Mol Cell. 2019 Aug 29;76(1):96–109.e9. doi: 10.1016/j.molcel.2019.07.016

Figure 6. Immunofluorescence reveals circFOREIGN co-localization with RIG-I and K63-Ubn and YTHDF2 recruitment to m6A-modified circFOREIGN.

Figure 6.

A. CircFOREIGN co-localizes with RIG-I and K63-polyubiquitin chain. Representative field of view is shown.

B. Quantification of circFOREIGN colocalization with RIG-I and K63-Ubn (n = 152). Foci were collected across 10 fields of view across biological replicates and representative of replicate experiments.

C. 10% m6A circFOREIGN has increased co-localization with YTHDF2. Representative field of view is shown. Foci were collected across >10 fields of view and representative of replicate experiments.

D. Quantification of circFOREIGN and 10% m6A circFOREIGN colocalization with YTHDF2 and RIG-I. *p<0.05, Pearson’s χ² test.