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. Author manuscript; available in PMC: 2020 Oct 3.
Published in final edited form as: Mol Cell. 2019 Aug 29;76(1):96–109.e9. doi: 10.1016/j.molcel.2019.07.016

Figure 7. Model of circRNA induction of innate immune response through RIG-I.

Figure 7.

Unmodified circRNA interacts with RIG-I in the presence of K63-Ubn to induce MAVS filamentation, which triggers IRF3 dimerization and interferon production. m6A-modified circRNAs together with YTHDF2 repel RIG-I and does not initiate signaling.