KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies for Immunohistochemistry | ||
| Rabbit anti-Krt5 | Covance | Cat#PRB-160P; RRID: AB_291581 |
| Rabbit anti-Ki67 | Abcam | Cat#Ab16667; RRID: AB_302459 |
| Rat anti-BrdU | Abcam | Cat#Ab6326; RRID: AB_305426 |
| Mouse anti-Krt14 | Thermo Fisher | Cat#MA5–11599; RRID: AB_10982092 |
| Mouse anti-β-Tubulin III | Millipore | Cat#MAB1637; RRID: AB_1707889 |
| Rabbit anti-∆NP63 | BioLegend | Cat#619001; RRID: AB_2256361 |
| Mouse anti-P63 | Santa Cruz | Cat#sc-8431; RRID: AB_628091 |
| Rabbit anti-RelA | Santa Cruz | Cat#sc-372; RRID: AB_632037 |
| Rat anti-CD45 | Ebioscience | Cat#14–0451-81; RRID: AB_467250 |
| Rat anti-F4/80 | Bio-Rad | Cat#MCA497GA; RRID: AB_323806 |
| Rat anti-Ly6G | Biolegend | Cat#127601; RRID: AB_1089179 |
| Rat anti-CD3 | Ebioscience | Cat#14–0032-81; RRID: AB_467052 |
| Goat anti-OMP | Wako | Cat#544–10001; RRID: AB_2315007 |
| Goat anti Sox2 | Santa Cruz | Cat#sc-17320; RRID: AB_2286684 |
| Goat anti-CCL19 | R&D Systems | Cat#AF880; RRID: AB_2071545 |
| Rabbit anti-TNF-α | Cell Signaling | Cat#3707; RRID: AB_10691460 |
| Goat anti-CXCL10 | R&D Systems | Cat#AF-466-NA; RRID: AB_2292487 |
| Rat anti-Foxp3 | eBioscience | Cat#14–5773-82; RRID: AB_467576 |
| Chicken anti Krt18 | Abcam | Cat# ab14047; RRID: AB_2133173 |
| Rabbit anti PGP9.5 | Ultraclone | Cat# RA95101; RRID: AB_2313685 |
| Goat anti-CCL20 | R&D Systems | Cat# AF760; RRID: AB_355580 |
| Rabbit anti IL-6 | Novus | Cat# NB600–1131; RRID: AB10001997 |
| Mouse anti Human CCL2 | R&D Systems | Cat#MAB2791; RRID: AB_2071560 |
| Rabbit anti Human-CD45 | Abcam | Cat#Ab40763; RRID: AB_726545 |
| Mouse anti-CD45 | Biolegend | Cat#304002; RRID: AB_314390 |
| Mouse anti-human CD3 | Biolegend | Cat#300413; RRID: AB_314067 |
| Alexa Fluor® 488 anti-human CD3 | Biolegend | Cat#300454; RRID: AB_2564149 |
| Mouse anti-Human CD4 | BD Pharmingen | Cat#555344; RRID: AB_395749 |
| Alexa Fluor® 488 anti-β-Tubulin III | Biolegend | Cat#801203; RRID: AB_2564757 |
| Antibodies for Flow Cytometry | ||
| FITC anti-mouse CD45 | Biolegend | Cat#103107; RRID: AB_312972 |
| PE anti-Ms F4/80 | Biolegend | Cat#123109; RRID: AB_893498 |
| Alexa F 647 anti FOXP3 | Biolegend | Cat#320013; RRID: AB_439749 |
| PE/Cy7 anti-Ms CD4 | Biolegend | Cat#100421; RRID: AB_312706 |
| PerCP/Cy5.5 anti-Ms/Hu CD11b | Biolegend | Cat#101227; RRID: AB_893233 |
| PerCP-Cy™5.5 Rat Anti-Mouse CD3 | BD Pharmingen | Cat#560527; RRID: AB_1727463 |
| Alexa Fluor® 700 Rat Anti-Mouse Ly-6G | BD Pharmingen | Cat#561236; RRID: AB_10611860 |
| Chemicals, Peptides, and Recombinant Proteins | ||
| Dox food | Bio Serv | Cat#S3888 |
| BrdU | Sigma | Cat#B9285 |
| Lipopolysaccharides (LPS) | Sigma | Cat#L2880 |
| Zymosan A Bioparticles, Alexa Fluor 488 | Molecular Probes | Cat#Z23373 |
| True-Nuclea Transcription Factor Buffer | Biolegend | Cat#424401 |
| Alexa Fluor 488 Tyramide SuperBoost Kit | Life Technologies | Cat#B40912 |
| TNF-α | Peprotech | Cat#315–01A |
| Murine EGF | Peprotech | Cat#315–09 |
| Murine FGF-basic | Peprotech | Cat#450–33 |
| Murine CCL19 | Peprotech | Cat#250–27B |
| Murine CCL20 | Peprotech | Cat#250–27 |
| Critical Commercial Assays | ||
| SYBR Green PCR Master Mix | Applied Biosystems | Cat#4385612 |
| TaqMan Fast Universal PCR Master Mix | Applied Biosystems | Cat#4352042 |
| Mouse TNF alpha ELISA Kit | eBioscience | Cat#88–7324 |
| MAGnify ChiP Kit | Life Technologies | Cat#49–2024 |
| Deposited Data | ||
| Raw data files for RNA sequencing | NCBI | GEO: GSE135042 |
| Experimental Models: Organisms/Strains | ||
| Mouse: Cyp2g1-rtTA | N/A | (Lane et al., 2010) |
| Mouse: TRE-TNF-α | N/A | (Vuillemenot et al., 2004) |
| Mouse: Krt17-EGFP | Jackson lab | Stock Number: 023965 |
| Mouse: Krt5-Cre | N/A | (Leung et al., 2007) |
| Mouse: Rosa26-stopflox/flox-tdTomato | Jackson lab | Stock Number: 007914 |
| Mouse: RelAflox/flox | N/A | (Luedde et al., 2008) |
| Oligonucleotides | ||
| qRT-PCR primers | This paper | Table S1–3 |
| Software and Algorithms | ||
| Prism 6 | Graphpad | https://www.graphpad.com |
| R | r-project.org | R 3.4.4 |
| Zen lite | Zeiss | ZEN 2012 (blue edition) |
| FlowJo v10 | FlowJo, LLC | flowjo.com |
| DAVID Bioinformatics Resources | (Huang da et al., 2009) | david.ncifcrf.gov |