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. 2019 Oct 4;9:14354. doi: 10.1038/s41598-019-50877-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TFEB increases the expression of Nrf2-response genes. (a) The protein levels of Nrf2-response genes in H4 cells (Control) and H4 cells stably expressing TFEB (TFEB) were analyzed by immunoblotting using anti-TFEB, Nrf2, HO-1, GSTM1, p62, and NDP52 antibodies, respectively. Full blots are provided in Supplementary Fig. S10. (b) The mRNA levels of Nrf2-response genes were analyzed by qRT-PCR as described in Methods. Bar graph represents the relative mRNA level of genes in TFEB cells compared to H4 cells. Data shown are mean ± S.E. of three independent experiments and were analyzed using Student’s t test. (*p < 0.05; ***p < 0.001).