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. 2019 Oct 4;9:14324. doi: 10.1038/s41598-019-50550-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Morphometric analyses of wild-type and dy^3K/dy^3K rectus femoris throughout the disease course. (a) Quantification of regenerating fibres. The number of centrally nucleated regenerating myofibres is increased in dy^3K/dy^3K muscle compared to wild-type muscle from postnatal day 4 onwards (p = 0.0401, p = 0.0004, p = 0.0004, p < 0.0001, for day 4, 7, 14 and 21, respectively). (b) The number of muscle fibres per 0.1 mm² (rectus femoris). Muscle fibres are temporarily lost at the age of 4 and 7 days in dy^3K/dy^3K rectus femoris (p = 0.002 and p = 0.0024, respectively). (c) Analysis of muscle fibre sizes from wild-type and dy^3K/dy^3K rectus femoris (day 1, 4, 7, 14 and 21). Muscle atrophy becomes evident in 14-day-old dystrophic muscles, and the shift towards significantly smaller muscle fibres is particularly pronounced at day 21.