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. 2019 Oct 4;9:14314. doi: 10.1038/s41598-019-50043-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Imaging of RA in mice by NIR detection. (a) The near infrared images of the dorsal side of arthritic mice at 2, 6 and 24 hours after an intravenous injection of NP or Folate-NP. (b) The quantification of fluorescence signal after normalization within the inflamed foot shown in panel A (green circles). *P < 0.05. Number 6 has two inflamed paws: front paw No. 6a and hind paw No. 6b (Ventral side is presented in supplemental figure 5).