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. 2019 Oct 4;9:14299. doi: 10.1038/s41598-019-50528-y

Figure 2.

Figure 2

Microphotographs (×40) from tumor and tumor-adjacent, non-cancerous samples. (a) NF-κB2 in a grade II, squamous lung carcinoma with strong and intermediate cytoplasmic staining without nuclear signal, (b) NF-κB2 intermediate cytoplasmic staining in adenocarcinoma, (c) strong and intermediate cytoplasmic signal for NF-κB2 in an undifferentiated large-cell carcinoma, (d) negative immunostaining for NF-κB2 protein in alveolar epithelium and interstitium of tumor-adjacent non-neoplastic lung parenchyma, (e) RelB immunodetection in a grade III, squamous-cell carcinoma with strong cytoplasmic staining, (f) strong nuclear and cytoplasmic staining for RelB protein in grade III lung adenocarcinoma, (g) representative section of undifferentiated large-cell, lung carcinoma with strong cytoplasmic signal for RelB, (h) negative immunostaining for RelB in alveolar epithelium and interstitium of tumor-adjacent non-neoplastic lung parenchyma from a squamous-cell carcinoma, (i) representative section from a grade I, squamous -cell carcinoma with strong cytoplasmic staining for NIK, (j) intermediate cytoplasmic staining for NIK in an adenocarcinoma, (k) strong cytoplasmic immunostaining for NIK in large-cell lung carcinoma, (l) negative immunostaining for ΝΙΚ in alveolar epithelium and interstitium of adjacent non-neoplastic lung parenchyma from a large-cell carcinoma, (m) representative section of grade I, squamous-cell carcinoma with strong cytoplasmic and intermediate nuclear staining for Bcl3, (n) strong cytoplasmic staining for Bcl3 in a lung adenocarcinoma, (o) intermediate nuclear and strong cytoplasmic staining for Bcl3 protein in a large-cell lung carcinoma, (p) negative immunostaining for Bcl3 in alveolar epithelium of tumor-adjacent, non-neoplastic lung parenchyma.