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Mutational analysis of the ICAM-1 binding site from group B PfEMP1. The different sites of contact between the IT4var13 DBLβ domain and ICAM-1D1D2 and the residues involved in the binding site are shown. For SPR measurements, 2-fold dilution series from 250 nM to 0.9 nM of wild-type (wt) or mutant IT4var13 DBLβ were injected over ICAM-1D1D5-Fc immobilized on a Protein A sensor chip. Sensorgrams show the data (black lines) and the fit of a 2-state reaction model (red lines).
