Table 4.
Analysis of tHcy interaction with risk factors in both men and women with H-type hypertension.
| Variables | tHcy, μmol/L | P for interaction | ||||||
|---|---|---|---|---|---|---|---|---|
| ≥18.0 | 13.1–17.9 | ≤13.0 | ||||||
| Coefficient | SE | OR (95% CI) | Coefficient | SE | OR (95% CI) | |||
| Men | ||||||||
| Age, years | 0.040 | |||||||
| <55, n = 309 | 0.179 | 0.430 | 1.196 (0.514–2.781) | −0.029 | 0.440 | 0.971 (0.410–2.299) | 1.00 (Referent) | |
| ≥55, n = 1020 | 0.415 | 0.211 | 1.514 (1.001–2.292) | −0.094 | 0.206 | 0.910 (0.608–1.362) | 1.00 (Referent) | |
| SBP, mmHg | 0.001 | |||||||
| <160, n = 754 | 0.283 | 0.205 | 1.328 (0.888–1.986) | −0.274 | 0.205 | 0.760 (0.509–1.137) | 1.00 (Referent) | |
| ≥160, n = 575 | 0.538 | 0.427 | 1.712 (0.741–3.954) | 0.343 | 0.416 | 1.410 (0.623–3.187) | 1.00 (Referent) | |
| DBP, mmHg | 0.002 | |||||||
| <90, n = 463 | 0.334 | 0.289 | 1.396 (0.793–2.458) | −0.202 | 0.280 | 0.817 (0.472–1.415) | 1.00 (Referent) | |
| ≥90, n = 866 | 0.682 | 0.256 | 1.978 (1.197–3.269) | 0.079 | 0.247 | 1.082 (0.667–1.755) | 1.00 (Referent) | |
| Women | ||||||||
| Age, years | <0.001 | |||||||
| <55, n = 149 | −0.591 | 0.616 | 0.554 (0.166–1.851) | −0.533 | 0.595 | 0.587 (0.183–1.884) | 1.00 (Referent) | |
| ≥55, n = 562 | 1.503 | 0.331 | 4.496 (2.348–8.606) | 0.467 | 0.233 | 1.595 (1.010–2.518) | 1.00 (Referent) | |
| SBP, mmHg | 0.003 | |||||||
| <160, n = 385 | 0.774 | 0.331 | 2.169 (1.133–4.153) | 0.158 | 0.265 | 1.172 (0.697–1.970) | 1.00 (Referent) | |
| ≥160, n = 326 | 2.056 | 0.671 | 7.818 (2.100–29.099) | 0.674 | 0.376 | 1.962 (0.939–4.098) | 1.00 (Referent) | |
| DBP, mmHg | <0.001 | |||||||
| <90, n = 289 | 0.604 | 0.398 | 1.829 (0.838–3.991) | 0.420 | 0.319 | 1.522 (0.814–2.843) | 1.00 (Referent) | |
| ≥90, n = 422 | 1.446 | 0.426 | 4.245 (1.841–9.791) | 0.388 | 0.296 | 1.474 (0.824–2.635) | 1.00 (Referent) | |
| FPG, mmol/L | 0.019 | |||||||
| <6.1, n = 426 | 0.980 | 0.362 | 2.663 (1.310–5.413) | 0.294 | 0.265 | 1.342 (0.799–2.255) | 1.00 (Referent) | |
| ≥6.1, n = 285 | 1.437 | 0.513 | 4.206 (1.540–11.486) | 0.617 | 0.394 | 1.853 (0.857–4.008) | 1.00 (Referent) | |
| TG, mmol/L | 0.009 | |||||||
| <2.3, n = 510 | 0.813 | 0.331 | 2.254 (1.178–4.312) | 0.322 | 0.253 | 1.379 (0.840–2.265) | 1.00 (Referent) | |
| ≥2.3, n = 201 | 1.334 | 0.551 | 3.795 (1.288–11.182) | 0.440 | 0.410 | 1.553 (0.695–3.469) | 1.00 (Referent) | |
Abbreviations: tHcy, total homocysteine; SE, standard error; OR, odds ratio; CI, confidence interval; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TG, triglycerides. Logistic regression models were adjusted for age, body mass index, SBP, DBP, FPG, TG, total cholesterol, high-density lipoprotein cholesterol, tHcy, cigarette smoking, alcohol consumption, MTHFR C677T polymorphism, and comorbidity.