Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 16;116(40):19983–19988. doi: 10.1073/pnas.1903678116

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published under the PNAS license.

PMC Copyright notice

Fig. 1. — Atp6ap2 β cell deletion induces the accumulation of large vacuolated structures. (A) Morphological analysis by hematoxylin and eosin staining in pancreases from WT and Atp6ap2^β-/y mice after TAM treatment for 3 and 8 wk. (B) Representative transmission electron microscopy images of β cells from WT and Atp6ap2^β-/y mice after 3 wk of TAM. Inset shows a representative single-membraned vacuole in Atp6ap2^β-/y islets. N, nucleus; SG, insulin secretory granule; *, dilated Golgi cisternae. (C) Rat insulinoma INS-1 cells were transfected with plasmid expressing Cas9-GFP and sgRNA targeting Atp6ap2. Successful clones deficient for Atp6ap2 (ΔAtp6ap2 INS-1 cells) were analyzed by transmission electron microscopy. Scale bars are indicated.