Fig. 4.

Regions of VDAC with increased protection upon interaction with mNT. Selected plots of deuterium incorporation into peptides from regions with significant increases in protection upon complex formation are shown. An additional plot is given (peptide 2 to 25) that is representative of peptides with no significant change in deuterium incorporation upon complex formation. This unaffected peptide corresponds to the N-terminal α-helix inside the VDAC barrel. Regions that exhibit significant increases in HD-exchange protection are highlighted on the VDAC crystal structure (PDB ID code 5XDO) in blue, and those without changes are in beige.