Fig. 1.

a Distribution of phosphorylated asyn (pASYN/Ab51253) pathology in sagittal brain sections of S129A PFF- and PBS-injected BAC rats at 4 months post-injection. The scale bar represents 1 mm in the whole brain sagittal sections (upper panel). In the lower panel, representative high-magnification photomicrographs of phosphorylated asyn (pASYN, Ab51253) pathology are shown in several brain areas of S129A PFF- and PBS-injected BAC rats: bulb, cortex, motor cortex (MC), striatum, hippocampus (HC), entorhinal cortex (EC), substantia nigra pars compacta (SNc), substantia nigra pars reticulata (SNr) hypothalamus (HypoT), dorsal motor nucleus of the vagus nerve (DMV), locus coeruleus (LC). The scale bar represents 100 µm in the DMV and LC, and 50 µm in all other brain areas. Similar levels of brain pathology were seen in the BAPFF and BACPBS rats, except for the brainstem (DMV, LC, and SNr), which contained significantly less or no pathology in the BACPBS rats. b Distribution of tyrosine hydroxylase in a sagittal brain section of BACPFF and BACPBS rats. Scale bar: 1 mm