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Evolutionary conservation analysis of 4 NOTCH3 mutations (p.P167S, p.P652S, p.R1100H, p.C709R; red boxes) (A–D). Protein sequences of Homo sapiens (NP_000426.2), Pan troglodytes (XP_009433184.1), Macaca mulatta (XP_014978652.1), Pongo abelii (XP_002828866.1), Theropithecus gelada (XP_025221819.1) and Papio anubis (XP_021786500.1) were retrieved from GenBank.
