Table 2.
The primary imaging findings of the 11 index patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy mutations.
| Index patients (proband) | Sex | Age | Stroke | White matter hyperintensity (WMH) | Lacunar lesions | Hemorrhage | Cerebral microbleeds (CMBs) | Dilated perivascular spaces (dPVS) | Brain atrophy |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 51 | Corpus callosum, centrum semiovale | Temporal pole, external capsule, periventricular area | Frontal lobe, basal ganglia | – | – | Basal ganglia | – |
| 2 | F | 72 | Centrum semiovale, corona radiata, posterior watershed | Temporal pole, external capsule, periventricular area | Frontal lobe, parietal lobe, basal ganglia | – | – | Basal ganglia, subcortex | – |
| 3 | F | 66 | Periventricular area | Temporal pole, external capsule, centrum semiovale | Frontal lobe, parietal lobe, basal ganglia | – | – | Basal ganglia, subcortex | – |
| 4 | F | 39 | Centrum semiovale, corona radiata, thalamus | Temporal pole, centrum semiovale, periventricular area | Occipital lobe | – | – | Basal ganglia | – |
| 5 | M | 53 | Centrum semiovale, corona radiata | Temporal pole, external capsule, centrum semiovale | Frontal lobe, basal ganglia | Brainstem, cerebellum, thalamus, basal ganglia, external capsule | – | Basal ganglia | – |
| 6 | F | 52 | Periventricular area, thalamus, frontal lobe | Temporal pole, centrum semiovale | Frontal lobe, basal ganglia | Brainstem, thalamus | – | Basal ganglia | – |
| 7 | M | 72 | Centrum semiovale, corona radiata, thalamus, basal ganglia, pons | Temporal pole, periventricular area, centrum semiovale | Frontal lobe, parietal lobe, basal ganglia | – | frontal lobe | Basal ganglia, subcortex | + |
| 8 | M | 43 | Basal ganglia, brainstem, callosum, frontotemporal lobe, hemicerebrum | Temporal pole, basal ganglia, external capsule | Occipital lobe | Basal ganglia | – | Basal ganglia | – |
| 9 | F | 81 | Thalamus, basal ganglia | Temporal pole, external capsule, periventricular area, centrum semiovale | Frontal lobe, parietal lobe, basal ganglia | – | – | Basal ganglia, subcortex | + |
| 10 | M | 47 | Pons, basal ganglia, thalamus, corona radiata, centrum semiovale | Temporal pole, centrum semiovale, corpus callosum, occipital lobe | Occipital lobe | – | – | Basal ganglia | + |
| 11 | F | 52 | Basal ganglia, thalamus, brainstem, cerebellum | Temporal pole, external capsule | Frontal lobe, occipital lobe, basal ganglia | – | – | Basal ganglia | – |