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. 2019 Oct 2;7:e7854. doi: 10.7717/peerj.7854

Figure 2. The expression of RUNX1 and its association with clinicopathologic variables.

Figure 2

The median value of RUNX1 expression was considered as the cut-off value. The Wilcoxon signed-rank test was utilized to investigate the relationship between clinicopathological factors and the expression of RUNX1 in 537 ccRCC tissues. The correlation between RUNX1 expression and overall survival (OS) was estimated using Kaplan–Meier survival curves. (A) Gender, (B) clinical stage, (C) tissue infiltration, (D) lymph node metastasis, (E) histological grade and (F) Kaplan–Meier survival curves showed that the prognosis of patients with ccRCC with high RUNX1 expression was worse than that of patients with ccRCC with low RUNX1 expression. In (C), positive indicates tissue infiltration and negative indicates no tissue infiltration. In (D), positive indicates lymph node metastasis and negative indicates no lymph node metastasis. RUNX1, Runt-related transcription factor 1; ccRCC, clear cell renal cell carcinoma; *, p < 0.05; **, p < 0.01; ***, p < 0.001.