Table 3. Association with overall survival and clinicopathological characteristics in patients from the TCGA database using Cox regression.
(A) Univariate Cox regression (B) Multivariate Cox regression.
| Clinicopathological variables | Hazard ratio (95% CI) | p-value |
|---|---|---|
| (A) | ||
| Age (continuous) | 1.02 (1.00–1.04) | 0.012 |
| Gender (male vs. female) | 1.01 (0.67–1.54) | 0.951 |
| RUNX1 expression (high vs. low) | 1.60 (1.31–1.97) | 0.000 |
| Grade | 2.24 (1.68–2.99) | 0.000 |
| Stage | 1.86 (1.54–2.25) | 0.000 |
| Distant metastasis (positive vs. negative)a | 4.07 (2.63–6.30) | 0.000 |
| Tissue infiltration (positive vs. negative)b | 3.31 (2.17–5.06) | 0.000 |
| Lymph node metastasis (positive vs. negative)c | 2.93 (1.52–5.67) | 0.001 |
| (B) | ||
| Age (continuous) | 1.03 (1.01–1.05) | 0.002 |
| RUNX1 expression (high vs. low) | 1.50 (1.20–1.87) | 0.000 |
| Distant metastasis (positive vs. negative) | 2.42 (1.14–5.16) | 0.022 |
Notes.
a
Positive indicates distant metastasis and negative indicates no distant metastasis.
b
Positive indicates tissue infiltration and negative indicates no tissue infiltration.
c
Positive indicates lymph node metastasis and negative indicates no lymph node metastasis.