Table 1.
Studies Evaluating Topometric and Topographic Pentacam Parameters in Detecting Clinical Keratoconus
| Study | Cut-off Value | Sensitivity | Specificity | AUC |
|---|---|---|---|---|
| CKI | ||||
| Orucoglu et al [50] | 1.015 | 0.727 | 0.982 | 0.824 |
| Chan et al [51] | 1.02 | 0.670 | 0.950 | 0.840 |
| Shetty et al [52] | 1.03* | 0.792 | 0.686 | 0.900 |
| Hashemi et al [53] | 1.014 | 0.652 | 0.970 | 0.714 |
| Uçakhan et al [54] | 1.015 | 0.864 | 0.857 | 0.877 |
| KI | ||||
| Orucoglu et al [50] | 1.055 | 0.910 | 0.982 | 0.970 |
| Chan et al [51] | 1.050 | 0.870 | 0.910 | 0.854 |
| Huseynli et al [55] | 1.04* | 0.933 | 0.979 | 0.994 |
| Shetty et al [52] | 1.07 | 1.000 | 0.657 | 0.954 |
| Uçakhan et al [54] | 1.125 | 0.864 | 0.857 | 0.907 |
| IHA | ||||
| Kovács et al [56] | - | 0.850 | 0.870 | 0.900 |
| Orucoglu et al [50] | 8.65 | 0.757 | 0.886 | 0.883 |
| Chan et al [51] | 12.15* | 0.730 | 0.910 | 0.913 |
| Shetty et al [52] | 21 | 0.708 | 0.800 | 0.892 |
| Hashemi et al [53] | 9.5 | 0.707 | 0.929 | 0.872 |
| Luz et al [57] | 10.1 | 0.723 | 0.956 | 0.890 |
| Uçakhan et al [54] | 11.6 | 0.841 | 0.794 | 0.852 |
| IHD | ||||
| Kovács et al [56] | - | 0.950 | 0.980 | 0.970 |
| Orucoglu et al [50] | 0.0175 | 0.900 | 0.890 | 0.951 |
| Chan et al [51] | 0.020 | 0.930 | 0.910 | 0.975 |
| Lopes et al [58] | 0.0205* | 0.995 | 0.988 | 1.000 |
| Huseynli et al [55] | 0.013 | 0.967 | 0.969 | 0.979 |
| Haddad et al [59] | 0.015 | 0.971 | 0.988 | - |
| Shetty et al [52] | 0.016 | 1.000 | 0.457 | 0.968 |
| Hashemi et al [53] | 0.012 | 0.900 | 0.906 | 0.949 |
| Luz et al [57] | 0.021 | 0.893 | 0.985 | 0.974 |
| Uçakhan et al [54] | 0.0335 | 0.909 | 0.794 | 0.886 |
| ISV | ||||
| Orucoglu et al [50] | 31.5 | 0.878 | 0.962 | 0.954 |
| Chan et al [51] | 24.0 | 0.930 | 0.910 | 0.990 |
| Lopes et al [58] | 32.5* | 0.945 | 0.987 | 0.995 |
| Shetty et al [52] | 41 | 1.000 | 0.700 | 0.972 |
| Hashemi et al [53] | 33 | 0.803 | 0.946 | 0.945 |
| Luz et al [57] | 35 | 0.904 | 0.980 | 0.977 |
| Uçakhan et al [54] | 59 | 0.841 | 0.905 | 0.924 |
| IVA | ||||
| Orucoglu et al [50] | 0.255 | 0.913 | 0.964 | 0.963 |
| Chan et al [51] | 0.160 | 0.930 | 0.910 | 0.992 |
| Huseynli et al [55] | 0.240* | 0.978 | 0.958 | 0.996 |
| Shetty et al [52] | 0.32 | 1.000 | 0.700 | 0.955 |
| Hashemi et al [53] | 0.20 | 0.875 | 0.963 | 0.952 |
| Luz et al [57] | 0.32 | 0.876 | 0.976 | 0.958 |
| Uçakhan et al [54] | 0.455 | 0.909 | 0.841 | 0.903 |
| Rmin | ||||
| Orucoglu et al [50] | 7.085 | 0.968 | 0.807 | 0.929 |
| Chan et al [51] | 7.320* | 0.930 | 0.910 | 0.984 |
| Shetty et al [52] | 6.71 | 0.917 | 0.771 | 0.771 |
| Hashemi et al [53] | 7.21 | 0.919 | 0.833 | 0.932 |
| Uçakhan et al [54] | 6.545 | 0.952 | 0.636 | 0.943 |
| PE | ||||
| Kovács et al [56] | - | 0.960 | 0.950 | 0.980 |
| Xu et al [60] | 30.165 | 0.940 | 0.880 | 0.970 |
| Lopes et al [58] | 16.5 | 0.945 | 0.979 | 0.988 |
| Mihaltz et al [61] | 15.5 | 0.951 | 0.943 | 0.970 |
| Huseynli et al [55] | 11.0 | 1.000 | 0.994 | 0.999 |
| Haddad et al [59] | 14.0 | 0.962 | 0.989 | - |
| Ambrósio et al [14] | 12.0 | 0.963 | 0.988 | 0.991 |
| Ambrósio et al [14] | 8.0 | 0.950 | 0.991 | 0.994 |
| Jafarinasab et al [62] | 35.0 | 0.939 | 0.886 | 0.977 |
| Uçakhan et al [54] | 26.5 | 0.977 | 0.810 | 0.926 |
| De Sanctis et al [63] | 35.0 | 0.973 | 0.969 | 0.990 |
| Muftuoglu et al [64] | 15.0* | 0.980 | 1.000 | 0.999 |
| Kamiya et al [65] | 14.0 | 0.921 | 0.952 | 0.898 |
Abbreviations: AUC: area under the curve; CKI: central keratoconus index; KI: keratoconus index; IHA: index of height asymmetry; IHD: index of height decentration; ISV: index of surface variance; IVA: index of vertical asymmetry; Rmin: minimum radius of curvature; PE: posterior elevation. *denotes cut-off point with best area under the curve if more than one study evaluated index accuracy. Highlighted indices represent the parameters that were included in the final evaluation of proposed thresholds.