Figure 3.

OSSL_325096 induces apoptosis in bortezomib‐resistant multiple myeloma (MM) cells and primary MM cells from two bortezomib‐refractory patients but not in PBMC from a healthy donor. Dot plots of cells treated with DMSO or 1 or 2 μmol/L OSSL_325096 with annexin V and 7‐AAD staining. A, KMS11 or KMS11/BTZ cells were treated with DMSO, 5 nmol/L bortezomib (Bor), or 1 μmol/L or 2 μmol/L OSSL_325096 for 48 h. B, Primary myeloma cells derived from two patients or PBMC from a healthy donor were treated with DMSO, 1 μmol/L, or 2 μmol/L OSSL_325096 for 48 h