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. 2019 Aug 14;110(10):3275–3287. doi: 10.1111/cas.14154

Figure 6.

Figure 6

OSSL_325096 downregulated BCL2 and upregulated cell cycle and heat shock‐related proteins. Gene set enrichment analysis (GSEA) was carried out based on RNA‐seq data of KMS12PE and KMS11 cells treated with DMSO or 1 μmol/L OSSL_325096. GSEA with >2 fold downregulated genes (A), and GSEA with >2 fold upregulated genes (B), with their maximum average RPKM of more than 50 were carried out. C,D, Real‐time PCR analysis of H1F0 and bcl2 (C), and HSPA1B, HSPA8,CDC20,SFN, and SKBP4 (D) in KMM1 and KMS12PE myeloma cells treated with 10 μmol/L of DBeQ. Means ± SD are shown. RPKM, Reads Per Kilobase of transcript, per Million mapped reads