Figure 7.

OSSL_325096 suppressed multiple myeloma (MM) cell proliferation in vivo without lethal toxicity. KMS12PE or KMS11 cells were s.c. transplanted into Rag2 ^−/− Jak3 ^−/− BALB/c mice and 50 mg/kg OSSL_325096 or vehicle was given to the mice i.p. after subcutaneous tumors became visible. A, Tumor volumes are presented as mean ± SD. Arrows indicate number of days of OSSL_325096 or vehicle dosage. B, Body weights of mice were monitored every week after giving OSSL_325096 or vehicle. Body weight at day 1 was regarded as baseline (set as 100%). Body weight is presented as mean ± SD. Significance values are indicated as *P < .05, **P < .01, ***P < .001 (Student's t‐test)