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. 2019 Oct 7;367:l5460. doi: 10.1136/bmj.l5460

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Fig 2 — Network diagrams of comparisons on different outcomes of treatments in different groups of patients with advanced epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC). (A) Comparisons on progression free survival and overall survival in patients with advanced EGFR mutated NSCLC. (B) Comparisons on objective response rate and adverse events of grade 3 or higher in patients with advanced EGFR mutated NSCLC. (C) Comparisons on progression free survival and overall survival in subgroups of study patients with exon 19 deletion (Ex19del) and Leu858Arg mutation types. Each circular node represents a type of treatment. The node size is proportional to the total number of patients receiving a treatment (in brackets). Each line represents a type of head-to-head comparison. The width of lines is proportional to the number of trials comparing the connected treatments. PbCT=pemetrexed based chemotherapy; PfCT=pemetrexed free chemotherapy