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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Neurosurg. 2019 Jul 1;131(1):1–13. doi: 10.3171/2019.3.JNS181724

FIG. 5.

FIG. 5.

A: 3D volumetric micro-CT scan of a mouse brain with a rich repertoire of CA lesions, which developed by the 3rd month of life in the Ccm3± Trp53−/− model. B: 3D volumetric micro-CT of a mouse brain with a robust cluster of CA lesions, which developed in the hindbrain by the 10th day of life, after tamoxifen injection on postnatal day 1, inducing an endothelial Ccm3−/− state in mice expressing endothelial-specific Pdgfb promoter–driven tamoxifen-regulated Cre recombinase in combination with loxP-flanked Pdcd10 exon 4. C: Photomicrograph illustrating the histological characteristics of a primordial CA lesion, consisting of a single ballooned capillary, without bleeding, a nonheme iron deposit, or inflammatory cell infiltrate (H&E, bar = 200 μM). D: Multicavernous mature CA with all the histological features of human lesions with hemosiderin deposits (H&E, bar = 200 μM). E: Process of image acquisition by micro-CT, 3D reconstruction, and semiautomated volumetric assessment of the lesion burden.