Skip to main content
. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Orthop Res. 2019 Jul 22;37(11):2401–2410. doi: 10.1002/jor.24404

Figure 4.

Figure 4.

Relative changes in chondrocyte transcript expression for A) COL1A1, B) COL2A1, C) ratio of COL2A1/COL1A1, D) MMP13, E) COX2 and F) NFKB1, post-treatment with either bolus PRGF (1% w/v) or PRGF releasates collected from PEG hydrogels on day 1, 4, and 11 (complete gel degradation). All samples except control (no IL-1β pre-treatment of PRGF treatment) were pre-treated with IL-1β (25 ng/mL) for 24 h and then were either given no treatment or treated with bolus PRGF or PRGF releasates. Data is averaged from 5 to 6 patient samples and normalized to control chondrocytes. Similar lower-case letters denote statistical significance (p<0.05).treatment) were pre-treated with IL-1β (25 ng/mL) for 24 h and then were either given no treatment or treated with bolus PRGF or PRGF releasates. Data is averaged from 6 patient samples and normalized to control chondrocytes. Similar lower-case letters denote statistical significance (p<0.05).