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Fold change in sGAG content in cartilage explants after treatment with either bolus PRGF (1% w/v) or PRGF releasates collected from PEG hydrogels on day 1 and 4. All data is averaged from 5 patient samples. sGAG was determined using DMMB assay. sGAG content of each explant was normalized to explant dry weight. A fold change for each condition was calculated with respect to a control explant maintained in 1% FBS media (no IL-1β pre-treatment of PRGF treatment).
