Skip to main content
. Author manuscript; available in PMC: 2019 Oct 7.
Published in final edited form as: Nat Rev Cancer. 2010 Aug;10(8):537–549. doi: 10.1038/nrc2887

Figure 3 |. HSP90 modulates nuclear events.

Figure 3 |

Four examples of the effect of heat shock protein 90 (HSP90) on nuclear events are shown. a | The androgen receptor (AR) exemplifies the importance of HSP90 in steroid hormone receptor (SHR) function. b | The importance of HSP90 in regulating heat shock transcription factor 1 (HSF1) activity is also shown. c | The effect of HSP90 on SMYD3-mediated histone methylation and its effect on the transcription of cancer-associated genes, such as NKX, WNT and C/EBP. d | An HSP90–BCL6 complex suppresses the transcription of several tumour suppressor genes and contributes to tumorigenesis. ATR, ataxia telangiectasia and Rad3-related; DHT, dihydrotestosterone; HRE, hormone response element; HSE, heat shock element; P, phosphorylation; PSA, prostate-specific antigen; RNA Pol II, RNA polymerase II.