Table II.
Gene ontology analysis of differentially expressed genes in association with clinical parameters in oral squamous cell carcinoma.
| Category/term | N (%) | P-value | Genes |
|---|---|---|---|
| GOTERM_CC_DIRECT | |||
| GO:0005576~extracellular region | 34 (19.1) | 2.12×10−6 | GC, DCD, C7, BPIFB6, STATH, GAST, HTN3, TAC3, SPINK7, SPINK9, TTR, ALB, GP2, PIP, LTF, FGF3, PRB2, CRISP3, BPIFA2, SCUBE3, BPIFA1, OPRPN, R3HDML, DHRS7C, MUC6, IL22, PLG, NTS, C4ORF26, CST5, WIF1, SCGB3A2, SMR3A, DMBT1 |
| GO:0005615~extracellular space | 29 (16.3) | 1.12×10−5 | GC, DCD, BPIFB2, PRH2, MSMB, C6ORF58, SPINK1, GAST, OSTN, SCGB1A1, TAC3, ZG16B, TTR, ALB, PIP, LTF, TFF1, FGFBP2, CRISP3, BPIFA1, OPRPN, IL22, PLG, CST5, SCGB3A1, EPYC, MUC5B, DMBT1, SMR3B |
| GO:0005882~intermediate filament | 6 (3.4) | 0.002961 | KRT36, KRT27, KRT40, KRTAP17-1, KRTAP19-5, KRTAP13-2 |
| GO:0070062~extracellular exosome | 38 (21.3) | 0.004723 | GC, DCD, C7, BPIFB2, PKHD1, C6ORF58, ALDOB, AQP5, SPINK1, CRNN, CALB1, SCGB1A1, TAC3, ZG16B, TTR, KRT27, ALB, UPK1A, GP2, PIP, LTF, TGM3, KRT84, CRISP3, GSTA2, BPIFA2, VIL1, ARMC3, MUC7, PLG, LRRC26, KRT36, PYGM, CST5, SCGB3A1, MUC5B, DMBT1, SMR3B |
| GOTERM_BP_DIRECT | |||
| GO:0001895~retina homeostasis | 5 (2.8) | 2.38×10−4 | ZG16B, ALB, PIP, LTF, OPRPN |
| GO:0046541~saliva secretion | 3 (1.7) | 5.68×10−4 | CHRM1, STATH, AQP5 |
| GO:0007506~gonadal mesoderm development | 3 (1.7) | 0.001567 | TSPY2, TSPY1, TSPY10 |
| GO:0030855~epithelial cell differentiation | 5 (2.8) | 0.002003 | GSTA2, UPK1A, VIL1, DMBT1, ACTL8 |
| GO:1900004~negative regulation of serine-type endopeptidase activity | 3 (1.7) | 0.00362 | SPINK9, SPINK1, SPINK7 |
| GO:0007548~sex differentiation | 3 (1.7) | 0.01426 | TSPY1, DMRT1, TSPY10 |
| GO:1900229~negative regulation of single-species biofilm formation in or on host organism | 2 (1.1) | 0.015188 | BPIFA1, LTF |
| GO:0060349~bone morphogenesis | 3 (1.7) | 0.017868 | LTF, IFITM5, PAX1 |
| GO:0042742~defense response to bacterium | 5 (2.8) | 0.02499 | DCD, BPIFA2, STATH, HTN3, MUC5B |
| GO:0043367~CD4-positive, alpha-beta T cell differentiation | 2 (1.1) | 0.037541 | PAX1, NKX2-3 |
| GOTERM_MF_DIRECT | |||
| GO:0005509~calcium ion binding | 12 (6.7) | 0.033232 | MYL7, SCUBE3, ANXA10, MYL3, CAPSL, RPTN, VIL1, TGM3, PCDHA11, CRNN, CALB1, NECAB2 |
| GO:0005499~vitamin D binding | 2 (1.1) | 0.040216 | GC, CALB1 |
| GO:0004867~serine-type endopeptidase inhibitor activity | 4 (2.2) | 0.045216 | SPINK9, SPINK1, TFPI2, SPINK7 |
GO, Gene Ontology.