Table 4.

The top 10 GO annotations enrichment of upregulated differentially expressed host linear transcripts affected by EA intervention.

Gene function	Number of genes	P	False discovery rate	Differentially expressed genes
Cellular macromolecule metabolic process	73	<0.05	<0.05	CNPT1, ARID1A, STRN3, DKC1, GAB1, EZH2, MBD2, NCOA2, SOX6, ZEB1, etc.
Positive regulation of biological process	59	<0.05	<0.05	GAB1, EIF4G3, TGFBR2, PDE5A, ADCY9, ASPH, SULF1, CNOT1, CTCF, DNMT1, etc.
Macromolecule metabolic process	74	<0.05	<0.05	BRD4, CTCF, DNMT1, ETV6, EZH1, EZH2, HECTD1, UBE3A, KLHL7, KIF16B, etc.
Single-organism cellular process	93	<0.05	<0.05	CTCF, ZFP207, BRD4, ANP32B, GAB1, IARS, HECTD1, CNOT1, CLIC4, SULF1, etc.
Cellular metabolic process	78	<0.05	<0.05	MED13L, ACAACA, SDHC, ADCY9, ASCC3, STK39, RABGEF1, EIF4G3, ELF1, PLAGL1, etc.
Positive regulation of cellular process	53	<0.05	<0.05	GAB1, EIF4G3, TGFBR2, ADCY9, Adam10, ADNP, UBE3A, CTCELF1, SOX6, etc.
Single-organism process	98	<0.05	<0.05	OPTN, CTCF, ZFP207, BRD4, ANP32B, CIGALT1, UBE3A, TGFBR2, ST6GALNAC3, ST3GAL5, etc.
Regulation of cellular metabolic process	57	<0.05	<0.05	EIF4G3, RABGEF1, STK39, OPTN, KIF16B, RERE, ELF2, MLLT3, ATAD2, GPBP1, etc.
Regulation of macromolecule metabolic process	57	<0.05	<0.05	AGO2L, ELF1, ADNP, ARID4B, EIF4G3, TGFBR2, PLAGL1, CD46, PIK3CB, UBE2K, etc.
Regulation of metabolic process	60	<0.05	<0.05	BRD41, CTCF, DNMT1, ETV6, EZH1, EZH2, ATAD2B, PDGFD, ERBB2IP, DKC1, etc.