Table 5.

The top 10 GO annotations enrichment of downregulated differentially expressed host linear transcripts affected by EA intervention.

Gene function	Number of genes	P	False discovery rate	Differentially expressed genes
Cellular metabolic process	90	<0.05	<0.05	POLA1, WHSC1, HIPK2, HOXB3, NFKB1, RAD23B, RAD52, FBXO18, ST3GAL6, PLCG2, etc.
Single-multicellular organism process	69	<0.05	<0.05	CBFB, SP3, PRKCA, MAP3K7, NRIP1, TNRC6C, IKZF1, NFKB1, NEK1, LATS2, etc.
Cellular macromolecule metabolic process	79	<0.05	<0.05	POLA1, WHSC1, HIPK2, HOXB3, NFKB1, PIAS1, ZBTB20, PRDM5, PHF14, EHMT1, etc.
Multicellular organism development	61	<0.05	<0.05	PRKCA, MAP3K7, NRIP1, CHM, ATF6, NEK1, LATS2, TSC2, IFT57, ARID11A, etc.
Metabolic process	95	<0.05	<0.05	CBFB, ARIH2, UBE2D2A, ANKIB1, TRIP12, ARID1A, STRN3, MAP3K7, PRKCA, DUSP3, etc.
Animal organ development	47	<0.05	<0.05	NRIP1, ATF6, SP3, IKZF1, NEK1, PLCG2, WHSC2, WHSC1, ZFPM1, MATR3, etc.
Primary metabolic process	88	<0.05	<0.05	PICALM, PRPSAP2, PIP5K1B, MECR, PLCG2, CD2AP, EP400, MLLT10, TTC7B, FAM126A, etc.
Regulation of cellular metabolic process	63	<0.05	<0.05	ZMYM5, EFEMP1, SP3, POU2F1, AFF3, IFT57, GON4L、TNRC6C, LARP4B, RPS6KB1, etc.
Regulation of macromolecule metabolic process	63	<0.05	<0.05	TCEA1, PLCG2, FBX018, RBM4, DUSP3, PRKCA, BOLL, TSC2, MATR3, PTPN22, etc.
Organic substance metabolic process	90	<0.05	<0.05	ARIH2, UBE2D2A, ANKIB1, TRIP12, STRN3, RSRC11, CDK13, SRBD1, ERI3, CCNE1, etc.