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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: Cell. 2019 Aug 22;178(5):1041–1056. doi: 10.1016/j.cell.2019.07.045

Figure 1. Genetic interactions between host and microbiome.

Figure 1.

Associations between host genetics and microbiome features can be identified by integrating GWAS SNPs into polygenic risk scores for pathways relevant to IBD pathology and microbiome features into coherent functional pathways. The objective of this strategy is to identify statistical associations between host and microbiome pathways that reveal causal mechanisms by which the host and microbiome interact to impact IBD.