Table 2. Effect of GEF on Various Parameters in CFA Induced Arthritis in Rats.
| Number of Days | Paw Volume (ml) | Arthritis Index | Body Weight (g) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Disease Control | Diclofenac Treated | GEF Treated | Control | Disease Control | Diclofenac Treated | GEF Treated | Control | Disease Control | Diclofenac Treated | GEF Treated | |
| 0 | 0.021 + 0.001 | 0.025 + 0.002 |
0.026 + 0.001 | 0.031 + 0.002 | 0 | 0 | 0 | 0 | 244.52 + 17.13 | 227.98 + 11.23 | 258.3 + 12.8 | 249.36 + 9.01 |
| 1 | 0.0220 + 0.001 |
0.750 + 0.065a |
0.790 + 0.052 | 0.960 + 0.085c | 0 | 2.6 + 0.44a | 1.4 + 0.21b | 1.6 + 0.245 b | 245.34 + 16.9 |
228.96 + 11.17 | 259.44 + 12.58d | 250.14 + 8.85 |
| 5 | 0.0351 + 0.002 |
2.080 + 0.084 a |
0.618 + 0.041b | 0.746 + 0.070 b | 0 | 2.8 + 0.32 a | 1.2 + 0.28 b | 1. 4+ 0.38 b | 250.66 + 17.27 |
226.98 + 11* | 261.06 + 12.37 d | 253.52 + 8.74 e |
| 12 | 0.0480 + 0.004 |
1.926 + 0.063 a |
0.490 + 0.036 b | 0.690 + 0.063 b | 0 | 2.4 + 0.48 a | 1.2 + 0.26 b | 1.0 + 0.20 b | 257.86 + 20.43 |
240.02 + 12.09 | 269.66 + 9.45 d | 262.16 + 6.90 |
| 16 | 0.0740 + 0.006 |
1.890 + 0.097 a |
0.490 + 0.032 b | 0.670 + 0.059 b | 0 | 2.0 + 0.36 a | 1.0 + 0.31 b | 1.0 + 0.34c | 259.38 + 20.31 |
241.58 + 11.42 | 272.2 + 8.97 d | 265.26 + 6.86 e |
| 21 | 0.1140 + 0.015 |
1.510 + 0.054 a |
0.250 + 0.022 b | 0.240 + 0.021 b | 0 | 1.6 + 0.51 a | 1.0+ 0.33d | 1.0 + 0.26d | 262.5 + 19.9 |
246.46 + 9.8 | 275.34 + 9.57 d | 268.32 + 7.71 e |
ap < 0.0001, *p < 0.05 as compared to control, bp < 0.0001, cp < 0.001, dp < 0.01, ep < 0.05 as compared to disease control animals, using one way ANOVA followed by Sidak’s multiple comparison test. Each value represents Mean + S.E.M. (n = 6, the number of animals utilized during experiment).