. Author manuscript; available in PMC: 2019 Oct 7.

Published in final edited form as: Pediatr Res. 2018 Dec 17;85(3):398–404. doi: 10.1038/s41390-018-0256-9

Table 3.

Concentrations of Biomarkers for Generalized Inflammation and Cardiomyocyte Injury in 28 Rhesus Macaque Monkeys after Receiving Methylphenidate for Five Years, by Dosage Group

	Methylphenidate dosage (mg/kg, bid)
Serum Biomarker	Control group (0) n=9	Low-dose group (2.5) n=9	High-dose group (12.5) n=10	P^*
hsCRP, mean (SD), mg/dL	0.92 (0.52)	1.73 (1.93)	1.97 (1.03)	0.20
Soluble TNF R1, mean (SD), U/mL	1.36 (0.37)	1.25 (0.30)	1.21 (0.32)	0.60
Myoglobin, mean (SD), ng/mL	2182 (974)	1882 (798)	979 (142)	0.006
IL 6, % detectable	44.4	33.3	60.0	0.57
IL 10, % detectable	22.2	66.7	60.0	0.20
TNF alpha, % detectable	66.7	77.8	70.0	0.99
Cardiac troponin I, % detectable	11.1	22.2	10.0	0.82

hsCRP, high sensitivity C reactive protein; TNF, tumor necrosis factor; R1, receptor 1; IL, interleukin. Probability values for statistical differences in means and percentages between dosage groups were calculated with exact permutation tests. Percent detectable is the percent of animals in each group with detectable concentrations.

Type I error rate (α) =0.01.