. Author manuscript; available in PMC: 2019 Oct 7.

Published in final edited form as: Pediatr Res. 2018 Dec 17;85(3):398–404. doi: 10.1038/s41390-018-0256-9

Table 4.

Concentrations of Cardiovascular Biomarkers in 28 Rhesus Macaque Monkeys after Receiving Methylphenidate for Five Years, by Dosage Group

Methylphenidate Dosage (mg/kg, bid)
Biomarker	Control group (0) n=9	Low-dose group (2.5) n=9	High-dose group (12.5) n=10	P^*
Glucose, mean (SD), mg/dL	68.4 (8.9)	62.1 (5.8)	67.6 (11.6)	0.30
Insulin, mean (SD), uU/mL	7.30 (6.01)	4.17 (4.15)	8.09 (13.5)	0.75
Total cholesterol, mean (SD), mg/dL	119 (20.1)	111 (15.2)	118 (25.1)	0.70
Triglycerides, mean (SD), mg/dL	37.9 (6.5)	41.1 (20.1)	46.4 (5.8)	0.53
HDL, mean (SD), mg/dL	66.2 (13.4)	60.3 (15.7)	60.7 (13.2)	0.62
LDL, mean (SD), mg/dL	45.3 (10.1)	42.8 (7.9)	48.4 (17.2)	0.61
VLDL, mean (SD), mg/dL	7.56 (1.33)	8.22 (4.09)	9.20 (3.71)	0.55
BMI, mean (SD), kg/m²	12.68 (0.94)	12.72^** (0.81)	12.93 (0.56)	0.76

HDL, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; VLDL, very low density lipoprotein cholesterol; BMI, body mass index. Probability values for statistical differences in means between dosage groups were calculated with exact permutation tests.

Type I error rate (α) =0.01.

^**

n=8.