Table 2.
Multiple extracellular matrix (ECM) proteins and carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) were identified among the top 35 most abundant exosomal proteins from patients with PDAC compared to IPMN without microinvasive cancer and other benign diseases.
| Proteins | Genes | PDAC (n=13) | IPMNca (n=4) | IPMN (n=4) | Benign (n=5) | p-value | PDAC (LFQ*) | IPMNca (LFQ*) | IPMN (LFQ*) | Benign (LFQ*) |
|---|---|---|---|---|---|---|---|---|---|---|
| Carcinoembryonic antigen-related cell adhesion molecule 1 | CEACAM1 | 12 | 0 | 0 | 1 | <0.001 | 28.7 | 0 | 0 | 27.2 |
| Tenascin C | TNC | 11 | 1 | 0 | 1 | 0.002 | 28.9 | 29.9 | 0 | 26.5 |
| Matrix metalloproteinase-7 | MMP7 | 9 | 0 | 0 | 0 | 0.002 | 28.2 | 0 | 0 | 0 |
| Laminin subunit beta-3 | LAMB3 | 8 | 1 | 0 | 0 | 0.006 | 28.5 | 26.9 | 0 | 0 |
| Laminin subunit gamma-2 | LAMC2 | 8 | 1 | 0 | 0 | 0.006 | 29.6 | 28.5 | 0 | 0 |
| Carcinoembryonic antigen-related cell adhesion molecule 5 | CEACAM5 | 9 | 1 | 1 | 0 | 0.012 | 28.8 | 27.9 | 27.9 | 0 |
PDAC, pancreatic ductal adenocarcinoma; IPMN, intraductal papillary mucinous neoplasm; IPMNca, IPMN with microinvasive cancer; LFQ, label-free quantification
*
median LFQ was reported only for those present in patients of each cohort.