Table 3.
CEACAM 1/5 and tenascin C staining intensity and pattern differentiates patients with PDAC from IPMN without microinvasive cancer.
| PDAC (n=27) | IPMN (n=12) | p-value | |
|---|---|---|---|
| CEACAM 1/5 staining on tumor epithelial cells | |||
| Staining intensity | |||
| Weak (1) | 0 (0%) | 0 (0%) | 0.401 |
| Moderate (2) | 7 (26%) | 2 (17%) | |
| Strong (3) | 20 (74%) | 10 (83%) | |
| Staining pattern | |||
| Membranous + luminal | 23 (0 focal, 23 diffuse) | 6 (1 focal, 5 diffuse) | 0.026 |
| Membranous only | 1 (1 focal, 0 diffuse) | 0 (0 focal, 0 diffuse) | |
| Luminal only | 3 (2 focal, 1 diffuse) | 6 (4 focal, 2 diffuse) | |
| Total score on membranous part of epithelial tumor cells | |||
| < 4 | 4 (15%) | 6 (50%) | 0.020 |
| ≥ 4 | 23 (85%) | 6 (50%) | |
| Tenascin C staining on stroma | |||
| Staining intensity | |||
| Weak (1) | 0 (0%) | 4 (33%) | 0.002 |
| Moderate (2) | 10 (37%) | 6 (50%) | |
| Strong (3) | 17 (63%) | 2 (17%) | |
| Staining pattern | |||
| Focal (1) | 13 (48%) | 12 (100%) | 0.002 |
| Diffuse (2) | 14 (52%) | 0 (0%) | |
| Total score | |||
| < 4 | 8 (30%) | 10 (83%) | 0.002 |
| ≥ 4 | 19 (70%) | 2 (17%) | |
PDAC, pancreatic ductal adenocarcinoma; IPMN, intraductal papillary mucinous neoplasm The staining pattern was scored as negative (0), focal (1), and diffuse (2), while staining intensity was scored as weak (1), moderate (2), or strong (3). The expression for CEACAM 1/5 and tenascin C was accepted as positive if a total score of ≥ 4 was obtained from combined staining intensity and pattern.