Effects of H2O2 on the α1 Na/K-ATPase-associated
Src. Purified Na/K-ATPase was first exposed to 10 mM H2O2
for 30 min, then to 1 U catalase to decompose the excess
H2O2. Pretreated Na/K-ATPase was incubated with
purified Src in the presence of 150 mM NaCl, 5 mM KCl, 100 μM vanadate,
10 μM ouabain, as indicated, and assayed for Src Tyr418 phosphorylation
as described under Material and methods. Representative immunoblots and
quantitative data from at least three independent experiments are shown.
n=3–5. Values are expressed as the
mean±SE. **p<0.01 compared with
control.