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. 2019 Sep 30;10:880. doi: 10.3389/fgene.2019.00880

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Copyright © 2019 Zhang, Lu, Wu and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic landscape of long noncoding RNAs (lncRNAs) in colorectal cancer (CRC) revealed LINC00460 as a candidate gene. (A) Volcano of 75 different expressed lncRNAs between tumor and adjacent normal tissues from The Cancer Genome Atlas (TCGA) database. Heatmap of 20 lncRNAs which contained both expression (B) and methylation (C) data. (D) Pearson correlation between expression and methylation of two hypomethylated lncRNAs (LINC00460 and FIRRE). ***p < 0.001.