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. 2019 Sep 30;10:880. doi: 10.3389/fgene.2019.00880

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Copyright © 2019 Zhang, Lu, Wu and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CpG island methylation of LINC00460. (A) Correlation between seven CpG methylation islands and LINC00460 expression screened from TCGA database. (B) Four islands showing a significant negative correlation with LINC00460 expression. (C) CpG island methylation statue between tumor and normal. (D) Heatmap of four CpG sites methylation in LINC00460 promoter. Three subgroups were identified by hierarchical clustering analysis in tumor. The DNA methylation in normal tissue is shown as the control. ***p < 0.001.