Table 2. Top 15 enriched gene ontology terms of the upregulated and downregulated DEGs.

Category	Term	Count	P-value	State
BP	Oxidation-reduction process	17	1.10E-04	Upregulated
BP	Proteolysis	11	0.01703296	Upregulated
BP	Long-chain fatty-acyl-CoA biosynthetic process	6	3.93E-05	Upregulated
BP	Response to organic cyclic compound	4	0.01023923	Upregulated
BP	Response to endoplasmic reticulum stress	4	0.031611372	Upregulated
CC	Extracellular exosome	74	2.91E-19	Upregulated
CC	Integral component of membrane	65	0.001627446	Upregulated
CC	Plasma membrane	56	7.29E-04	Upregulated
CC	Membrane	34	0.00188457	Upregulated
CC	Extracellular space	27	1.58E-04	Upregulated
MF	Calcium ion binding	13	0.032748281	Upregulated
MF	Oxidoreductase activity	9	5.26E-04	Upregulated
MF	Actin binding	9	0.004195153	Upregulated
MF	Serine-type peptidase activity	7	2.40E-05	Upregulated
MF	Serine-type endopeptidase activity	7	0.030442507	Upregulated
BP	Positive regulation of transcription from RNA polymerase II promoter	8	0.047270726	Downregulated
BP	Negative regulation of transcription from RNA polymerase II promoter	7	0.034624047	Downregulated
BP	Negative regulation of cell growth	4	0.008047189	Downregulated
BP	Extracellular matrix organization	4	0.028910713	Downregulated
BP	Collagen fibril organization	3	0.007739592	Downregulated
CC	Extracellular exosome	23	3.41E-05	Downregulated
CC	Extracellular space	20	2.27E-08	Downregulated
CC	Extracellular region	15	4.96E-04	Downregulated
CC	Extracellular matrix	6	0.002673098	Downregulated
CC	Blood microparticle	4	0.013152355	Downregulated
MF	Protein binding	34	0.021626321	Downregulated
MF	Drug binding	4	0.001392245	Downregulated
MF	Protein dimerization activity	4	0.009398722	Downregulated
MF	ATPase activity	4	0.016027571	Downregulated
MF	Sodium:potassium-exchanging ATPase activity	2	0.028658029	Downregulated

Note:

BP, biological process; CC, cell component; MF, molecular function.