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Chemical structures of the new generation of azoles VNI and VFV, and old azoles ravuconazole and posaconazole that inhibit the T. cruzi sterol 14 α-demethylase. VNI [20] and VFV [21] are new promising drug candidates in pre-clinical studies, whereas ravuconazole and posaconazole entered unsuccessful clinical trials [139,11].
