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. 2019 Sep 26;13:1033. doi: 10.3389/fnins.2019.01033

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Copyright © 2019 Balashova, Pershin, Zaborskaya, Tkachenko, Mironov, Guryev, Kurbatov, Gainullin and Mukhina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Open field test results at the time point 48 h. Hyal animals in Open field test show neither increase nor decrease in anxiety and exploratory behavior versus vehicle group on time points of 48 h. There was no difference in locomotor activity of animals as indicated by traveled distance (A). Time spent by animals in center and periphery of Open field didn’t differ as well (B). Anxiety level of Hyal animals didn’t differ refer to Vehicle group as was shown by rearing and grooming analysis (C,D). Figures show mean ± SEM, N = 10 per group. Two-way ANOVA and Mann–Whitney test didn’t reveal any significant difference (p > 0.05).