Primary function in vivo	K+ dependent MAPK activation	Histone Modification	Mitochondrial fragmentation	deSUMOylation/Ubc9 degradation	Caspase-1 activation	Macrophage TLR4 activation	Effects on cell adhesion	Protein translocation	Vacuolar Escape
CDC	Organism
Listeriolysin O (LLO)	Listeria monocytogenes	Escape from the vacuole	(Gonzalez et al., 2011; Tang, Rosenshine, Cossart, & Finlay, 1996)	(Hamon et al., 2007)	(Stavru et al., 2011)	(Ribet et al., 2010)	(Meixenberger et al., 2010; Sauer et al., 2010)	(Park, Ng, Maeda, Rest, & Karin, 2004)	(Drevets, 1997; Kayal et al., 1999; Krüll et al., 1997)	(Sibelius et al., 1996)	(Tilney, L. G., Portnoy, 1989)
Perfringolysin (PFO)	Clostridium perfringens	Disruption of neutrophil migration (Ellemor et al., 1999)		(Hamon et al., 2007)		(Ribet et al., 2010)		(Park et al., 2004)	(Bryant & Stevens, 1996; Rafii, Park, Bryant, Johnson, & Wagner, 2008)		(O’Brien & Melville, 2004)
Pneumolysin (PLY)	Streptococcus pneumoniae	Epithelial barrier disruption (Rayner et al., 1995) Transmission (Zafar et al., 2017)	(Aguilar et al., 2009)	(Hamon et al., 2007)		(Li et al., 2017; Ribet et al., 2010)	(Fang et al., 2011; Hassane et al., 2017; Karmakar et al., 2015; Witzenrath et al., 2011)	(Malley et al., 2003; Srivastava et al., 2005)	(Nel et al., 2017; Thornton & McDaniel, 2005; Zhang et al., 2016)
Streptolysin O (SLO)	Streptococcus pyogenes	Cell killing by SPN translocation (Zhu et al., 2017)	(Stassen et al., 2003)			(Li et al., 2017)	(Harder et al., 2009; Keyel et al., 2013)	(Park et al., 2004)	(Bryant et al., 2005; Zhang et al., 2016)	(Madden et al., 2001)
Suilysin (SLY)	Streptococcus suis		(Bi et al., 2015)			(Li et al., 2017)		(Bi et al., 2015)	(Zhang et al., 2016)
Anthrolysin O (ALO)	Bacillus anthracis		(Ratner et al., 2006)					(Park et al., 2004)			(Tonello & Zornetta, 2012)
Vaginolysin (VLY)	Gardnerella vaginalis		(Gelber, Aguilar, Lewis, & Ratner, 2008)
Other Pore-forming molecules
T3SS				(Dortet et al., 2018)	(Dortet et al., 2018)		(McCoy, Koizumi, Higa, & Suzuki, 2010)			(Wagner et al., 2018)
Aerolysin	Aeromonas hydrophila		(Gonzalez et al., 2011)	(Hamon & Cossart, 2011)			(Gurcel et al., 2006; McCoy et al., 2010)