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Common Driver Mutations of Lung Adenocarcinomas
| Gene | Hotspot |
|---|---|
| Trunk drivers | |
| BRAF | Codon 600a |
| EGFR | Exons 18-21 |
| KRAS/NRAS | Codons 12, 13, 59, 61, 117, 146 |
| MET | Exon 14 skipping mutations |
| ALK, RET, ROS1 | Translocation |
| Branching drivers | |
| PIK3CA | Codons 542, 545, 1047 |
| TP53 | Exons 5-9 |
aOther BRAF mutations involving codons 466, 469, 594, and 601 may also be trunk driver mutations of lung adenocarcinomas.
