Table 2.
Fifteen Patients With Two to Three Metastatic Specimens
| Case No. | Metastatic Site | Seven-Gene Profilinga |
|---|---|---|
| MM01 | Brain (Re) | KRAS p.G12D |
| Brain (Re) | KRAS p.G12D | |
| MM02 | Chest wall (Re) | KRAS p.G12A |
| Brain (Re) | KRAS p.G12A | |
| MM03 | LN, right lower paratracheal (Re) | No mutation |
| LN, supraclavicular (Bx) | No mutation | |
| MM04 | LN, right lower paratracheal (FNA) | KRAS p.G12A |
| Pleural effusion (FNA) | KRAS p.G12A | |
| MM05 | Soft tissue (Bx) | KRAS p.G12C |
| Abdominal wall (Bx) | KRAS p.G12C | |
| MM06 | Brain, frontal (Re) | KRAS p.G12C, PIK3CA p.E545K |
| Brain, occipital (Re) | KRAS p.G12C, PIK3CA p.E545K | |
| MM07 | Pleura (Re) | KRAS p.G12V, NRAS p.G12D |
| Pleural effusion (FNA) | KRAS p.G12V, NRAS p.G12D | |
| MM08 | Liver (Bx) | KRAS p.G13D |
| Pleural effusion (FNA) | KRAS p.G13D | |
| MM09 | LN, right lower paratracheal (FNA) | KARS p.A146T, BRAF p.G466V |
| LN, supraclavicular (Bx) | KARS p.A146T, BRAF p.G466V | |
| MM10 | Pleural effusion (FNA) | EGFR p.L858R |
| Pleura (Re) | EGFR p.L858R | |
| MM11 | Pleural effusion (FNA) | KRAS p.G12A, PIK3CA p.E542K |
| Pleura (Re) | KRAS p.G12A, PIK3CA p.E542K | |
| MM12 | LN, cervical (Re) | No mutation |
| Adrenal (Bx) | No mutation | |
| MM13 | LN, subcarinal (FNA) | No mutation |
| LN, right hilar (FNA) | No mutation | |
| MM14b | LN, pretracheal (FNA) | NRAS p.G12D |
| Small bowel (Re) | NRAS p.G12D | |
| MM15 | Pleura (Re) | ERBB2 p.G778_P780dup |
| Liver (Bx) | ERBB2 p.G778_P780dup | |
| Liver (Bx) | ERBB2 p.G778_P780dup |
Bx, biopsy; FNA, fine-needle aspiration; LN, lymph node; Re, resection.
a AKT1, BRAF, EGFR, ERBB2, KRAS, NRAS, and PIK3CA genes.
bCase MM14 and case PM29 in Table 3 were submitted from the same patient with a primary tumor and two metastatic tumors.