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. Author manuscript; available in PMC: 2019 Oct 7.
Published in final edited form as: Nat Cell Biol. 2019 Feb;21(2):116–117. doi: 10.1038/s41556-019-0278-5

Fig. 1 ∣. A model for mRNA entry into stress granules.

Fig. 1 ∣

mRNA (black line) undergoing translation in a stressed cell is unable to reinitiate translation and condense as ribosomes (orange) run off. The condensed mRNA diffuses freely in the cytoplasm until a chance encounter with a stress granule (green). The mRNA makes transient contact with the granule surface and visits a P-body (blue) before entering the stress granule. Contacts are mediated by transient pairing interactions with resident granule mRNAs (grey), whose ends extend past the granule surface.